ABflo® 594 Rabbit anti-Human Flt3/CD135 Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A24382-100, A24382-200, A24382-500
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 108kDa/112kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 2322
SWISS: P36888
Alternate Names: FLT3; CD135; FLK-2; FLK2; STK1; fms related tyrosine kinase 3
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Signal Transduction, Kinase, Tyrosine kinases, Immunology and Inflammation, CD markers, Stem Cells
NCBI Alias: FLT3
Modifications: Unmodified
Conjugate: ABflo® 594. Ex:588nm. Em:604nm.
Clone Number Info: ARC63039
Research Use Only