ABflo® 647 Rabbit anti-Human PCSK9 Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A26380-100, A26380-200, A26380-500
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Category: Monoclonal Antibodies
Application: FC (intra)
Cross Reactivity: Human
Protein Weight: 74kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 255738
SWISS: Q8NBP7
Alternate Names: FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.
Recommended Dilution: FC (intra),5 μl per 10^6 cells in 100 μl volume
Research Areas: Epigenetics Nuclear Signaling, RNA Binding, Cancer, Apoptosis, Ubiquitin, Endocrine Metabolism, Amino acid metabolism, Lipid Metabolism, Cholesterol Metabolism, Stem Cells, Neural Stem Cells, Cardiovascular, Lipids
NCBI Alias: PCSK9
Modifications: Unmodified
Conjugate: ABflo® 647. Ex:648nm. Em:664nm.
Clone Number Info: ARC67621
Research Use Only