ABI1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A16092-20, A16092-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t (10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 55kDa
Observed Molecular Weight: 55-65kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 10006
SWISS: Q8IZP0
Alternate Names: E3B1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1; ABI1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, G protein signaling, Small G proteins, Kinase, Cell Biology Developmental Biology, Cell Cycle, Growth factors.
NCBI Alias: ABI1
Research Use Only