Product Description

ABR Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18508-50, ES18508-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ABR AA range: 393-443

Isotype: IgG

Target: ABR

Specificity: This antibody detects endogenous levels of ABR at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly enriched in the brain, Much weaker expression in heart, lung and muscle,

Molecular Weight (Da): 94kD

Function: Function: GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them
Similarity: Contains 1 C2 domain
Similarity: Contains 1 DH (DBL-homology) domain
Similarity: Contains 1 PH domain
Similarity: Contains 1 Rho-GAP domain
Tissue Specificity: Highly enriched in the brain. Much weaker expression in heart, lung and muscle

Subcellular Location: Cell projection, dendritic spine Cell projection, axon Cell junction, synapse

Storage and Stability: -20°C/1 year

Gene Name: ABR

Protein Name: ABR

Mouse Gene ID: 109934

Mouse SwissProt Number: Q5SSL4

Research Use Only