ACHA4 Rabbit pAb - A1648

ACHA4 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A1648-20, A1648-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.

Category: Polyclonal Antibodies

Applications: WB, IF/ICC, ELISA

Cross-reactivity: Mouse

Protein Weight: 70kDa

Observed Molecular Weight: 70kDa

Immunogen: Recombinant protein (or fragment)

Species: Human

GeneID: 1137

SWISS: P43681

Alternate Names: EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4; ACHA4

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Cancer, Endocrine Metabolism, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease.

NCBI Alias: CHRNA4

Research Use Only