Product Description

AChRα9 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8440-50, ES8440-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9)

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human CHRNA9. AA range:50-100

Isotype: IgG

Target: AChRα9

Specificity: AChRα9 Polyclonal Antibody detects endogenous levels of cholinergic receptor, nicotinic, alpha 9

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells,

Observed Band (KD): 55kD

Fields: Neuroactive ligand-receptor interaction, Chemical carcinogenesis - receptor activation

Function: Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion
Miscellaneous: The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic

Subcellular Location: Cell junction, synapse, postsynaptic cell membrane, Multi-pass membrane protein Cell membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CHRNA9

Protein Name: cholinergic receptor, nicotinic, alpha 9

Rat SwissProt Number: P43144

Research Use Only