Product Description

Actin-α/γ Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES6944-50, ES6944-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: ACTC1, ACTC, Actin, alpha cardiac muscle 1, Alpha-cardiac actin, ACTG1, ACTB, ACTG, Actin, cytoplasmic 2, Gamma-actin, ACTG2, ACTA3, ACTL3, ACTSG, Actin, gamma-enteric smooth muscle, Alpha-actin-3, Gamma-2-actin, Smooth muscle gamma-actin,

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Actin. AA range:21-70

Isotype: IgG

Target: Actin-α/γ

Specificity: Actin-α/γ Polyclonal Antibody detects endogenous levels of Actin-α/γ protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Muscle, Tongue,

Observed Band (KD): 45kD

Fields: Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy, Dilated cardiomyopathy

Function: Disease: Defects in ACTC1 are the cause of cardiomyopathy dilated type 1R (CMD1R) [MIM: 102540]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death
Disease: Defects in ACTC1 are the cause of cardiomyopathy familial hypertrophic type 11 (CMH11) [MIM: 612098]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death
Function: Actins are highly conserv

Subcellular Location: Cytoplasm, cytoskeleton

Storage and Stability: -20°C/1 year

Gene Name: ACTC1

Protein Name: Actin alpha cardiac muscle 1

Mouse Gene ID: 11464/11465/11468/11459

Rat Gene ID: 29275/100361457/25365/29437

Rat SwissProt Number: P68035/P63259/P63269/P68136

Research Use Only