Product Description

Actin-α/γ (Q49) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1500-50, BS1500-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: All eukaryotic cells express actin, which often constitutes as much as 50% of total cellμlar protein. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. While lower eukaryotes, such as yeast, have only one actin gene, higher eukaryotes have several isoforms encoded by a family of genes. At least six types of actin are present in mammalian tissues and fall into three classes. α actin expression is limited to various types of muscle, whereas β and γ are the principle constituents of filaments in other tissues. Members of the small GTPase family regμlate the organization of the actin cytoskeleton. Rho controls the assembly of actin stress fibers and focal adhesion, Rac regμlates actin filament accumμlation at the plasma membrane and Cdc42 stimμlates formation of filopodia.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Actin, alpha cardiac muscle 1, Alpha-cardiac actin, ACTC1, ACTC

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Synthetic peptide, corresponding to the N-terminal of Human Actin-α.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Actin-α/γ (Q49) polyclonal antibody detects endogenous levels of Actin-α/γ protein.

Molecular Weight: ~ 45 kDa

Pathway: Regμlation of Actin Dynamics,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P68032/P63261/P63267/P68133

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only