Actinin-α1 Polyclonal Antibody - RA21635

Actinin-α1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21635-50, RA21635-100

Citations, Manuals and MSDS Available upon request.

Background: actinin alpha 1 (ACTN1) Homo sapiens Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Condition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB: 1:1000-2000 IHC: 1:200-500

Alternative Names: ACTN1; Alpha-actinin-1; Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1

Applications: WB; IHC-p; IF (paraffin section)

Species Cross-Reactivity: Mouse; Rat

GeneID (Human): 87

Protein MW (KDa): 103

SWISS: P12814

Source: Rabbit

Research Use Only