Product Description

ACTR-IIA Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7986-50, ES7986-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: ACVR2A, ACVR2, Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, ACTRIIA

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human ACTR-IIA. AA range:10-59

Isotype: IgG

Target: ACTR-IIA

Specificity: ACTR-IIA Polyclonal Antibody detects endogenous levels of ACTR-IIA protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Mammary gland, Testis,

Observed Band (KD): 48kD

Fields: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, Fluid shear stress and atherosclerosis

Function: Catalytic Activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Cofactor: Magnesium or manganese
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A
Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily
Similarity: Contains 1 protein kinase domain
Subunit: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3

Subcellular Location: Membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: ACVR2A

Protein Name: Activin receptor type-2A

Mouse Gene ID: 11480

Mouse SwissProt Number: P27038

Rat Gene ID: 29263

Rat SwissProt Number: P38444

Research Use Only