Product Description

ADA11 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18463-50, ES18463-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ADA11 AA range: 600-650

Isotype: IgG

Target: ADA11

Specificity: This antibody detects endogenous levels of ADA11 at Human/Mouse

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.327% sodium azide.

Expression: Expressed predominantly in brain, Slightly detected or not at all in other tissues,

Observed Band (KD): 85kD

Function: Disease: Rearrangements occur in breast and ovarian cancers which involve multiple exons and disrupt the coding region
Domain: A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor
Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein
PTM: The precursor is cleaved by a furin endopeptidase
Similarity: Contains 1 disintegrin domain
Similarity: Contains 1 EGF-like domain
Similarity: Contains 1 peptidase M12B domain
Tissue Specificity: Expressed predominantly in brain. Slightly detected or not at all in other tissues

Subcellular Location: Membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: ADAM11 MDC

Protein Name: ADA11

Mouse Gene ID: 11488

Mouse SwissProt Number: Q9R1V4

Research Use Only