Product Description

ADAM9 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES9357-50, ES9357-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 120-200

Isotype: IgG

Target: ADAM9

Specificity: ADAM9 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Widely expressed, Expressed in chondrocytes, Isoform 2 is highly expressed in liver and heart,

Observed Band (KD): 90kD

Function: Caution: Has sometimes been referred to as ADAM-12
Cofactor: Binds 1 zinc ion per subunit
Function: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP
Similarity: Contains 1 disintegrin domain
Similarity: Contains 1 EGF-like domain
Similarity: Contains 1 peptidase M12B domain
Tissue Specificity: Widely expressed. Expressed in chondrocytes. Highest expression of isoform 2 found in liver and heart

Subcellular Location: [Isoform 1]: Cell membrane, Single-pass type I membrane protein, [Isoform 2]: Secreted

Storage and Stability: -20°C/1 year

Gene Name: ADAM9 KIAA0021 MCMP MDC9 MLTNG

Protein Name: Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myelo

Mouse SwissProt Number: Q61072

Research Use Only