Product Description

ADAT3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18458-50, ES18458-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a subunit of a tRNA-specific adenosine deaminase. This heterodimeric enzyme converts adenosine to inosine in the tRNA anticodon. A mutation in this gene causes a syndrome characterized by intellectual disability and strabismus. This gene shares its 5' exon with the overlapping gene, secretory carrier membrane protein 4 (Gene ID: 113178). [provided by RefSeq, Jul 2016],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ADAT3 AA range: 295-345

Isotype: IgG

Target: ADAT3

Specificity: This antibody detects endogenous levels of ADAT3 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 39kD

Function: Caution: Val-225 is present instead of the conserved Glu which is an active site in the cytidine and deoxycytidylate deaminase family of enzymes. It is suggested that this protein may act as a regulatory subunit
Cofactor: Zinc
Function: May be involved in deamination of adenosine-34 to inosine in many tRNAs as a regulatory subunit
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily

Subcellular Location: nucleoplasm, cytosol,

Storage and Stability: -20°C/1 year

Gene Name: ADAT3

Protein Name: ADAT3

Mouse Gene ID: 100113398

Mouse SwissProt Number: Q6PAT0

Rat Gene ID: 100125374

Rat SwissProt Number: Q561R2

Research Use Only