Product Description

ADCYA Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18455-50, ES18455-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ADCYA AA range: 368-418

Isotype: IgG

Target: ADCYA

Specificity: This antibody detects endogenous levels of ADCYA at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Detected in airway epithelial cells and testis (at protein level) (PubMed:17591988), Weakly expressed in multiple tissues, Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum, Very low level of expression in bone,

Molecular Weight (Da): 177kD

Fields: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Apelin signaling pathway, Circadian entrainment, Thermogenesis, Growth hormone synthesis, secretion and action

Function: Catalytic Activity: ATP = 3',5'-cyclic AMP + diphosphate
Cofactor: Binds 2 magnesium ions per subunit
Disease: Genetic variations in ADCY10 are associated with absorptive hypercalciuria type 2 (HCA2) [MIM: 143870]. Absorptive hypercalciuria (AH) is a common cause of calcium oxalate nephrolithiasis. Clinically, AH is characterized by intestinal hyperabsorption of calcium in the presence of normal serum calcium and immunoreactive PTH (iPTH). It is often accompanied by low bone mineral density (BMD), particularly of the lumbar spine. About 50% of patients with AH present with a family history of calcium oxalate nephrolithiasis and hypercalciuria
Enzyme Regulation: Activated by manganese or magnesium ions. In the presence of magnesium ions, the enzyme is activated by bicarbonate while in the presence of manganese ions, the enzyme is inhibited by bicarbonate. In the absence of magnesium and bic

Subcellular Location: Cell membrane, Peripheral membrane protein, Cytoplasmic side Cytoplasm, cytoskeleton Cytoplasm, perinuclear region Nucleus Cell projection, cilium Cytoplasm Mitochondrion Distributed to subcellular compartments containing cAMP targets Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin

Storage and Stability: -20°C/1 year

Gene Name: ADCY10 SAC

Protein Name: ADCYA

Mouse Gene ID: 271639

Mouse SwissProt Number: Q8C0T9

Rat Gene ID: 59320

Rat SwissProt Number: Q9Z286

Research Use Only