Adducin α (phospho-T445) Polyclonal Antibody
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Catalogue Numbers: BS4258-50, BS4258-100
Sizes: 50µl, 100µl
Swiss-Prot: P35611
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: IHC
Background: Adducins are a family of cytoskeleton proteins encoded by three genes (α, β, γ). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin α is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin α and Adducin γ is ubiquitous in contrast to the restricted expression of Adducin β. Adducin β is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Specificity: p-Adducin α (T445) polyclonal antibody detects endogenous levels of Adducin α protein only when phosphorylated at Thr445.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Immunohistochemistry (IHC) analysis of p-Adducin α (T445) pAb in paraffin-embedded human breast carcinoma tissue.
Bioworld Molecular Weight: ~ 81 kDa
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Alternative Name: Alpha-adducin; Erythrocyte adducin subunit alpha; ADD1; ADDA; α-Adducin; Adducin1; Adducin-1; α Adducin;
Immunogen: Synthetic phosphopeptide derived from human Adducin α around the phosphorylation site of Threonine 445.
Conjugate: Unconjugated
Modification: Phosphorylation