Product Description

ADM Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3932-50, ES3932-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014],

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: ADM, AM, ADM

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human ADM. AA range:101-150

Isotype: IgG

Target: ADM

Specificity: ADM Polyclonal Antibody detects endogenous levels of ADM protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highest levels found in pheochromocytoma and adrenal medulla, Also found in lung, ventricle and kidney tissues,

Observed Band (KD): 20kD

Fields: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction

Function: Function: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels
Similarity: Belongs to the adrenomedullin family
Tissue Specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: ADM

Protein Name: ADM

Mouse SwissProt Number: P97297

Rat Gene ID: 25026

Rat SwissProt Number: P43145

Research Use Only