Product Description

ADR1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18451-50, ES18451-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ADR1 AA range: 277-327

Isotype: IgG

Target: ADR1

Specificity: This antibody detects endogenous levels of ADR1 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed (PubMed:16044242), Highly expressed in heart and skeletal muscle (PubMed:12802337), Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337), Weakly expressed in colon, thymus and small intestine (PubMed:12802337),

Molecular Weight (Da): 41kD

Fields: AMPK signaling pathway, Longevity regulating pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease, Alcoholic liver disease

Function: Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin
Similarity: Belongs to the ADIPOR family
Subcellular Location: Localized to the cell membrane and intracellular organelles
Subunit: May form homo and heteromultimers
Tissue Specificity: Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine

Subcellular Location: Cell membrane, Multi-pass membrane protein Localized to the cell membrane and intracellular organelles

Storage and Stability: -20°C/1 year

Gene Name: ADIPOR1 PAQR1 TESBP1A CGI-45

Protein Name: ADR1

Mouse Gene ID: 72674

Mouse SwissProt Number: Q91VH1

Research Use Only