Product Description

ADR2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18450-50, ES18450-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA, MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ADR2 AA range: 62-112

Isotype: IgG

Target: ADR2

Specificity: This antibody detects endogenous levels of ADR2 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous (PubMed:16044242), Highly expressed in skeletal muscle, liver and placenta (PubMed:12802337), Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung (PubMed:12802337),

Molecular Weight (Da): 42kD

Fields: AMPK signaling pathway, Longevity regulating pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease, Alcoholic liver disease

Function: Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin
Online Information: Adiponectin entry,Similarity: Belongs to the ADIPOR family
Subcellular Location: Localized to the cell membrane and intracellular organelles
Subunit: May form homo and heteromultimers
Tissue Specificity: Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung

Subcellular Location: Cell membrane, Multi-pass membrane protein Localized to the cell membrane and intracellular organelles

Storage and Stability: -20°C/1 year

Gene Name: ADIPOR2 PAQR2

Protein Name: ADR2

Mouse Gene ID: 68465

Mouse SwissProt Number: Q8BQS5

Research Use Only