Product Description

AF9 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18444-50, ES18444-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human AF9 AA range: 328-378

Isotype: IgG

Target: AF9

Specificity: This antibody detects endogenous levels of AF9 at Human/Mouse

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.153% sodium azide.

Expression: Enriched in undifferentiated hematopoietic stem cells in fetal liver, cord blood and bone marrow,

Observed Band (KD): 60kD

Fields: Viral life cycle - HIV-1, Transcriptional misregulation in cancer

Function: Disease: A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9, 11)(p22, q23) with MLL/HRX. The result is a rogue activator protein
Similarity: Contains 1 YEATS domain
Subunit: Interacts with BCOR. Interacts with CBX8

Subcellular Location: Nucleus Chromosome Colocalizes with acylated histone H3 (PubMed:25417107, PubMed:27105114) Colocalizes with histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114)

Storage and Stability: -20°C/1 year

Gene Name: MLLT3 AF9 YEATS3

Protein Name: AF9

Mouse Gene ID: 70122

Mouse SwissProt Number: A2AM29

Research Use Only