Affinity Gel-conjugated Pan Succinyl-Lysine Rabbit mAb
Size: 100μg
Catalogue Number: A26021-100
Citations, Manuals and MSDS Available upon request.
Background: The lysine residue in proteins can undergo to many types of PTMs, such as methylation, acetylation, biotinylation, ubiquitination, ubiquitin-like modifications, propionylation and butyrylation, then leading to the remarkable complexity of PTM networks. Succinylation is a posttranslational modification (PTM) where a succinyl group is added to a Lys (K) residue of a protein molecule .it has been shown that the lysine succinylation responses to different physiological conditions and is evolutional conserved. It has been identified 2, 565 succinylation sites from 779 proteins and revealed that lysine succinylation have potential impacts on enzymes involved in mitochondrial metabolism including the amino acid degradation, tricarboxylic acid (TCA) cycle and fatty acid metabolism Thelysine succinylation also occurs in histones, suggesting that it may play an important role in regulating chromatin structures and functions as well
Category: Other Modified Antibodies
Applications: IP-MS
Cross-reactivity: Species independent
Immunogen: Synthetic peptide
Source: Rabbit
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 50% glycerol, 0.09% Sodium azide, pH 7.3.
Recommended Dilutions: IP-MS, 40 μL antibody (bead slurry) for 200μg-400μg extracts of whole cell
Research Areas: Protein Post-translational Modification, PTM.
NCBI Alias: Pan-Succinyl-K
Clone Number Info: ARC55837-AG
Research Use Only