Product Description

AL2CL Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18408-50, ES18408-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: ALS2 C-terminal-like protein

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human AL2CL AA range: 606-656

Isotype: IgG

Target: AL2CL

Specificity: This antibody detects endogenous levels of AL2CL at Human/Mouse

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.222% sodium azide.

Expression: Expressed in heart and kidney,

Observed Band (KD): 105kD

Function: Function: Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics
Similarity: Contains 1 VPS9 domain
Similarity: Contains 8 MORN repeats
Subcellular Location: Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells
Subunit: Homodimer. Forms a heteromeric complex with ALS2 (By similarity). Interacts with ALS2 and RAB5A
Tissue Specificity: Expressed in heart and kidney

Subcellular Location: Cytoplasm Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells

Storage and Stability: -20°C/1 year

Gene Name: ALS2CL

Protein Name: AL2CL

Mouse Gene ID: 235633

Mouse SwissProt Number: Q60I26

Research Use Only