Amphiregulin Polyclonal Antibody - BT-AP00413

Amphiregulin Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP00413-20, BT-AP00413-50, BT-AP00413-100

Citations, Manuals and MSDS Available upon request.

Background: The amphiregulin encoded by AREG is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions.

Research Areas: Signal Transduction; Cancer

Target Protein: AREG

Applications: WB, ELISA

Reactivity: Human

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Amphiregulin Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 27895

UniProt Accession: Human: P15514; Mouse: P31955; Rat: P24338

Synonyms: AREG; SDGF; AREGB; Amphiregulin; AR; Colorectum cell-derived growth factor; CRDGF

GeneID: Human: 374/727738; Mouse: 11839; Rat: 29183

Research Use Only