Product Description

AMRP Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18366-50, ES18366-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human AMRP AA range: 277-327

Isotype: IgG

Target: AMRP

Specificity: This antibody detects endogenous levels of AMRP at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 39kD

Fields: Cholesterol metabolism

Function: Disease: In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis
Function: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330
PTM: N-glycosylated
Similarity: Belongs to the alpha-2-MRAP family
Subcellular Location: Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum
Subunit: Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. Binds LRP1B, binding is followed by internalization and degradation

Subcellular Location: Rough endoplasmic reticulum lumen Endoplasmic reticulum-Golgi intermediate compartment lumen Golgi apparatus, cis-Golgi network Golgi apparatus lumen Endosome lumen Cell surface May be associated with receptors at the cell surface

Storage and Stability: -20°C/1 year

Gene Name: LRPAP1 A2MRAP

Protein Name: AMRP

Mouse Gene ID: 16976

Mouse SwissProt Number: P55302

Rat Gene ID: 116565

Rat SwissProt Number: Q99068

Research Use Only