Product Description

Angiotensin II Type 2 Receptor Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS45896-50, BS45896-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adμlt tissues, except brain, adrenal medμlla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection resμlt in down-regμlation of ACE2 (angiotensin converting enzyme-2) receptors which triggers serious inflammatory lesions, primarily in the lungs. The inflammatory reaction is mediated by angiotensin II derivatives, however, while the ACE2-angiotensin II-angiotensin AT1 receptor pathway contributes to the pathophysiology of ARDS (acute respiratory distress syndrome), the activation of the ACE-2-angiotensin(1-7)-angiotensin AT2 receptor and the ACE-2-angiotensin(1-7)-Mas receptor pathways have been shown to be protective. [provided by RefSeq, Jun 2020]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IP

Alternate Names: AT2, ATGR2, MRX88

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human Angiotensin II Type 2 Receptor

Dilution: WB: 1:1000-1:5000 IP: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 41 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P50052

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only