Product Description

ANGP2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18353-50, ES18353-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Angiopoietin-2 (ANG-2)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ANGP2

Isotype: IgG

Target: ANGP2

Specificity: This antibody detects endogenous levels of human ANGP2

Dilution: WB 1:500-2000, ELISA(peptide)1:5000-20000

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Colon, Lung, Substantia nigra, Umbilical vein endothelial cell,

Observed Band (KD): 55kD

Fields: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Kaposi sarcoma-associated herpesvirus infection

Function: Function: Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal
Online Information: Angiopoietin entry,Similarity: Contains 1 fibrinogen C-terminal domain

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: ANGPT2

Protein Name: ANGP2

Research Use Only