Product Description

ANO3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18338-50, ES18338-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ANO3 AA range: 518-568

Isotype: IgG

Target: ANO3

Specificity: This antibody detects endogenous levels of ANO3 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in the forebrain striatum,

Molecular Weight (Da): 108kD

Function: Function: May act as a calcium-activated chloride channel
Similarity: Belongs to the anoctamin family

Subcellular Location: Cell membrane, Multi-pass membrane protein Shows an intracellular localization

Storage and Stability: -20°C/1 year

Gene Name: ANO3 C11orf25 TMEM16C GENX-3947

Protein Name: ANO3

Mouse Gene ID: 228432

Mouse SwissProt Number: A2AHL1

Research Use Only