Product Description

ANO5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18336-50, ES18336-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the anoctamin family of transmembrane proteins. The encoded protein is likely a calcium activated chloride channel. Mutations in this gene have been associated with gnathodiaphyseal dysplasia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ANO5 AA range: 276-326

Isotype: IgG

Target: ANO5

Specificity: This antibody detects endogenous levels of ANO5 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in brain, heart, kidney, lung, and skeletal muscle, Weakly expressed in bone marrow, fetal liver, placenta, spleen, thymus, osteoblasts and periodontal ligament cells,

Molecular Weight (Da): 100kD

Function: Disease: Defects in ANO5 are the cause of gnathodiaphyseal dysplasia (GDD) [MIM: 166260], also called osteogenesis imperfecta with unusual skeletal lesions or gnathodiaphyseal sclerosis. GDD is a rare skeletal syndrome characterized by bone fragility, sclerosis of tubular bones, and cemento-osseous lesions of the jawbone. Patients experience frequent bone fractures caused by trivial accidents in childhood, however the fractures heal normally without bone deformity. The jaw lesions replace the tooth-bearing segments of the maxilla and mandible with fibrous connective tissues, including various amounts of cementum-like calcified mass, sometimes causing facial deformities. Patients also have a propensity for jaw infection and often suffer from purulent osteomyelitis-like symptoms, such as swelling of and pus discharge from the gums, mobility of the teeth, insufficient healing after tooth extr

Subcellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein Cell membrane, Multi-pass membrane protein Colocalized with CALR/calreticulin (PubMed:15124103) Shows an intracellular localization according to PubMed:22075693

Storage and Stability: -20°C/1 year

Gene Name: ANO5 GDD1 TMEM16E

Protein Name: ANO5

Mouse Gene ID: 233246

Mouse SwissProt Number: Q75UR0

Research Use Only