Product Description

Anti-Flu A (H3N2) HA/Hemagglutinin Broadly Neutralizing Reference Antibody (CR8020)

Sizes: 100ug, 1mg

Catalogue Numbers: VK515096-100, VK515096-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Description: CR8020 is a broadly neutralizing antibody (bNAb) targeting the stem region of influenza A virus (IAV) hemagglutinin (HA) and is in phase II trials for prophylactic use against group 2 IAVs. Structural and computational analyses show that CR8020 binds HA residues subject to antigenic drift and host selection pressure, with escape mutations observed in some H7N9 strains. Additionally, effective engagement of Fcγ receptors (FcγR) is crucial for antibody efficacy, but membrane steric hindrance may limit HA-CR8020-FcγR complex formation. These findings highlight epitope mutability and immune complex accessibility as key factors in bNAb development.

Reactivity: Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

Host: Human

Applications: ELISA, Bioactivity: FACS, Functional assay

Isotype: IgG1-lambda

Target: Hemagglutinin, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, HA

Purification: Protein A/G purified from cell culture supernatant.

Purity: >95% purity as determined by SDS-PAGE.

Expression System: Mammalian Cells

Storage and Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Storage Buffer: 0.01M PBS, pH 7.4.

Form: Liquid

Clone ID: CR8020

Accession: Q91MA7

Endotoxin Level: Please contact the lab for this information.

Research Use Only