Product Description

Anti-Human CD19 Reference Antibody (Coltuximab, RUO)

Sizes: 100ug, 1mg

Catalogue Numbers: HB996016-100, HB996016-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Description: Coltuximab ravtansine (SAR3419) is an antibody-drug conjugate (ADC) targeting CD19 created by conjugating a derivative of the potent microtubule-acting cytotoxic agent, maytansine, to a version of the anti-CD19 antibody, anti-B4, that was humanized as an IgG1 by variable domain resurfacing. Four different linker-maytansinoid constructs were synthesized (average ∼3.5 maytansinoids/antibody for each) to evaluate the impact of linker-payload design on the activity of the maytansinoid-ADCs targeting CD19. Anti-CD19 humanized monoclonal antibody conjugated to DM4.

Reactivity: Human

Host: Chimeric

Applications: ELISA, Bioactivity: FACS, Functional assay

Alternate Names: SAR3419, 1269764-99-9

Clonality: Monoclonal

Isotype: IgG1-kappa

Target: CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4

Purification: Protein A/G purified from cell culture supernatant.

Purity: >95% as determined by SDS-PAGE.

Expression System: Mammalian Cells

Storage and Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Storage Buffer: 0.01M PBS, pH 7.4.

Form: Liquid

Accession: P15391

Endotoxin Level: Contact Us for more information.

Research Use Only