Product Description

Anti-Human CD27/TNFRSF7 Reference Antibody (Varlilumab, RUO)

Sizes: 100ug, 1mg

Catalogue Numbers: HB796016-100, HB796016-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Description: Varlilumab is a fully human monoclonal antibody (mAb) that targets CD27, a critical molecule in the activation pathway of lymphocytes. Like CD40, CD27 can be effectively manipulated with activating antibodies to induce potent anti-tumor responses, and may result in less toxicities due to its restricted expression and regulation. Varlilumab is a novel, first-in-class, agonist CD27 antibody that stimulates the CD27 pathway, which results in T-cell activation and anti-tumor activity in tumor models. This first-in-human, dose-escalation and expansion study evaluated the safety, pharmacology, and activity of varlilumab in patients with advanced solid tumors.

Reactivity: Human

Host: Human

Applications: ELISA, Bioactivity: FACS, Functional assay

Alternate Names: 1F5, CDX-1127, 1393344-72-3

Clonality: Monoclonal

Isotype: IgG1-kappa

Target: CD27L receptor, TNFRSF7, T14, CD27 antigen, Tumor necrosis factor receptor superfamily member 7, CD27, T-cell activation antigen CD27

Purification: Protein A/G purified from cell culture supernatant.

Purity: >95% purity as determined by SDS-PAGE.

Expression System: Mammalian Cells

Storage and Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Storage Buffer: 0.01M PBS, pH 7.4.

Form: Liquid

Accession: P26842

Endotoxin Level: Please contact the lab for this information.

Research Use Only