Product Description

Anti-Human CD40/TNFRSF5 Reference Antibody (Sotigalimab, RUO)

Sizes: 100ug, 1mg

Catalogue Numbers: HB782116-100, HB782116-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Description: The FDA has granted an orphan drug designation to sotigalimab (APX005M) as a potential therapeutic option for patients with soft tissue sarcoma, according to an announcement from Apexigen Inc., the drug developer.A novel, humanized monoclonal antibody, sotigalimab was designed to stimulate an antitumor immune response and to target CD40, which is a key co-stimulatory receptor that serves to activate innate and adaptive immune systems. When sotigalimab binds to CD40 on antigen-presenting cells, it induces a multifaceted immune response that brings several components of the immune system together to attack the cancer.

Reactivity: Human

Host: Humanized

Applications: ELISA, Bioactivity: FACS, Functional assay

Alternate Names: APX005M, APX-005, APX-005-M, APX-005M, 2305607-45-6

Clonality: Monoclonal

Isotype: IgG1-Kappa

Target: Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, TNFRSF5, CDw40, CD40

Purification: Protein A/G purified from cell culture supernatant.

Purity: >95% purity as determined by SDS-PAGE.

Expression System: Mammalian Cells

Storage and Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Storage Buffer: 0.01M PBS, pH 7.4.

Form: Liquid

Accession: P25942

Endotoxin Level: Please contact the lab for this information.

Research Use Only