Product Description

Anti-Human Siglec-3/CD33 Reference Antibody (Lintuzumab, RUO)

Sizes: 100ug, 1mg

Catalogue Numbers: HB185026-100, HB185026-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Description: Lintuzumab is a humanized monoclonal antibody, HuM195, that targets the cell surface antigen CD33 that is expressed on the vast majority of acute myeloid leukemia (AML) cells. [225Ac]Ac-lintuzumab clinical trials were discussed in detail in reference. Lintuzumab is under investigation in clinical trial NCT00016159 (Chemotherapy Plus Monoclonal Antibody in Treating Patients With Acute Promyelocytic Leukemia).

Reactivity: Human

Host: Humanized

Applications: ELISA, Bioactivity: FACS, Functional assay

Alternate Names: 225Ac-lintuzumab, HuM195, SGN-33, SMARTM195, HuM195, 166089-32-3

Clonality: Monoclonal

Isotype: IgG1-kappa

Target: Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, CD33, gp67, SIGLEC3

Purification: Protein A/G purified from cell culture supernatant.

Purity: >95% purity as determined by SDS-PAGE.

Expression System: Mammalian Cells

Storage and Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Storage Buffer: 0.01M PBS, pH 7.4.

Form: Liquid

Accession: P20138

Endotoxin Level: Please contact the lab for this information.

Research Use Only