Product Description

AP1B1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18312-50, ES18312-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: AP-1 complex subunit beta-1 (Adapter-related protein complex 1 subunit beta-1) (Adaptor protein complex AP-1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human AP1B1 AA range: 215-265

Isotype: IgG

Target: AP1B1

Specificity: This antibody detects endogenous levels of AP1B1 at Human/Mouse/Rat

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.201% sodium azide.

Expression: Widely expressed,

Observed Band (KD): 105kD

Fields: Lysosome, Human immunodeficiency virus 1 infection

Function: Disease: Deletion of the AP1B1 gene may play a role in the tumorigenesis of meningiomas
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules
Similarity: Belongs to the adaptor complexes large subunit family
Subcellular Location: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex
Subunit: Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3)
Tissue Specificity: W

Subcellular Location: Golgi apparatus Cytoplasmic vesicle, clathrin-coated vesicle membrane, Peripheral membrane protein, Cytoplasmic side Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex

Storage and Stability: -20°C/1 year

Gene Name: AP1B1 ADTB1 BAM22 CLAPB2

Protein Name: AP1B1

Mouse Gene ID: 11764

Mouse SwissProt Number: O35643

Rat Gene ID: 29663

Rat SwissProt Number: P52303

Research Use Only