Product Description

AP1M2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18311-50, ES18311-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human AP1M2 AA range: 117-167

Isotype: IgG

Target: AP1M2

Specificity: This antibody detects endogenous levels of AP1M2 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 47kD

Fields: Lysosome, Human immunodeficiency virus 1 infection

Function: Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules
PTM: Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals
Similarity: Belongs to the adaptor complexes medium subunit family
Similarity: Contains 1 MHD (mu homology) domain
Subcellular Location: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex
Subunit: Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or A

Subcellular Location: Golgi apparatus Cytoplasmic vesicle, clathrin-coated vesicle membrane, Peripheral membrane protein, Cytoplasmic side Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex

Storage and Stability: -20°C/1 year

Gene Name: AP1M2

Protein Name: AP1M2

Mouse Gene ID: 11768

Mouse SwissProt Number: Q9WVP1

Research Use Only