Product Description

AP2B Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18310-50, ES18310-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human AP2B AA range: 18-68

Isotype: IgG

Target: AP2B

Specificity: This antibody detects endogenous levels of AP2B at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 51kD

Function: Disease: Defects in TFAP2B are the cause of Char syndrome (CHAR) [MIM: 169100]. CHAR is an autosomal dominant disorder characterized by patent ductus arteriosus (PDA), facial dysmorphism and hand anomalies
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia
Online Information: Activatin protein 2 entry,PTM: Sumoylated on Lys-21, which inhibits tran

Subcellular Location: Nucleus In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum

Storage and Stability: -20°C/1 year

Gene Name: TFAP2B

Protein Name: AP2B

Mouse Gene ID: 21419

Mouse SwissProt Number: Q61313

Research Use Only