Product Description

AP2S1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18307-50, ES18307-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human AP2S1 AA range: 26-76

Isotype: IgG

Target: AP2S1

Specificity: This antibody detects endogenous levels of AP2S1 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 16kD

Fields: Endocytosis, Synaptic vesicle cycle, Endocrine and other factor-regulated calcium reabsorption, Huntington disease

Function: Function: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP2S1/AP17 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositides
Similarity: Belongs to the adaptor complexes small subunit family
Subcellular Location: Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane
Subunit: Adaptor protein complex 2 (AP-2) is an heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1)

Subcellular Location: Cell membrane Membrane, coated pit, Peripheral membrane protein, Cytoplasmic side AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV

Storage and Stability: -20°C/1 year

Gene Name: AP2S1 AP17 CLAPS2

Protein Name: AP2S1

Mouse Gene ID: 232910

Mouse SwissProt Number: P62743

Rat Gene ID: 65046

Rat SwissProt Number: P62744

Research Use Only