Product Description

AP4A Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18305-50, ES18305-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human AP4A AA range: 93-143

Isotype: IgG

Target: AP4A

Specificity: This antibody detects endogenous levels of AP4A at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 16kD

Fields: Purine metabolism, Pyrimidine metabolism, Metabolic pathways

Function: Catalytic Activity: P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP
Cofactor: Divalent ions
Function: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis
Similarity: Belongs to the Nudix hydrolase family

Subcellular Location: mitochondrial matrix,

Storage and Stability: -20°C/1 year

Gene Name: NUDT2 APAH1

Protein Name: AP4A

Mouse Gene ID: 66401

Mouse SwissProt Number: P56380

Rat Gene ID: 297998

Rat SwissProt Number: Q6PEC0

Research Use Only