Product Description

AP4B1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18304-50, ES18304-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human AP4B1 AA range: 595-645

Isotype: IgG

Target: AP4B1

Specificity: This antibody detects endogenous levels of AP4B1 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed,

Molecular Weight (Da): 81kD

Fields: Lysosome

Function: Function: Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system
Similarity: Belongs to the adaptor complexes large subunit family
Subcellular Location: Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells
Subunit: Adapter-like complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1)
Tissue Specificity: Widely expressed

Subcellular Location: Golgi apparatus, trans-Golgi network membrane, Peripheral membrane protein

Storage and Stability: -20°C/1 year

Gene Name: AP4B1

Protein Name: AP4B1

Mouse Gene ID: 67489

Mouse SwissProt Number: Q9WV76

Research Use Only