Product Description

AP4E1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18303-50, ES18303-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human AP4E1 AA range: 104-154

Isotype: IgG

Target: AP4E1

Specificity: This antibody detects endogenous levels of AP4E1 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed,

Molecular Weight (Da): 125kD

Fields: Lysosome

Function: Function: Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system
Similarity: Belongs to the adaptor complexes large subunit family
Subcellular Location: Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells
Subunit: Adapter-like complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1)
Tissue Specificity: Widely expressed

Subcellular Location: Golgi apparatus, trans-Golgi network membrane, Peripheral membrane protein

Storage and Stability: -20°C/1 year

Gene Name: AP4E1

Protein Name: AP4E1

Mouse Gene ID: 108011

Mouse SwissProt Number: Q80V94

Research Use Only