Product Description

APOC1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18289-50, ES18289-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: IHC, ELISA

Alternate Names: Apolipoprotein C-I (Apo-CIB, ApoC-IB, Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I (Apo-CIB', ApoC-IB')]

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human APOC1 AA range: 1-50

Isotype: IgG

Target: APOC1

Specificity: This antibody detects endogenous levels of human APOC1

Dilution: IHC-p 1:50-200, ELISA(peptide)1:5000-20000

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Synthesized mainly in liver and to a minor degree in intestine, Also found in the lung and spleen,

Fields: Cholesterol metabolism

Function: Function: Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein
Miscellaneous: Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein)
Online Information: Apolipoprotein C1 entry,Similarity: Belongs to the apolipoprotein C1 family
Tissue Specificity: Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: APOC1 APOC1B

Protein Name: APOC1

Research Use Only