Product Description

AR-α1A (Q365) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS2207-50, BS2207-100

Sizes: 50µl, 100µl

Swiss-Prot: P35348

Host: Rabbit

Reactivity: Human

Applications: WB, IHC, IF

Background: α1A-adrenergic receptors (α1A-ARs) mediate actions in the sympathetic nervous system through the binding of the catecholamines, epinephrine and norepinephrine. α1A-AR couples to Gq/11 and regulates blood pressure due to changes in vascular tone and cardiac output. Alternative splicing of the ADRA1A gene generates four isoforms with distinct C-termini, and the different expression profile of these subtypes produces distinct patterns of activation. α1A-AR transcripts are abundant in heart, brain, liver and prostate. α1A-AR transcript sizes of 6.0, 4.0, 3.0, and 2.0 kb have been detected in liver. Transcripts of 6.0, 4.0 and 3.0 kb have been detected in heart, and transcripts of 6.0 and 4.0 kb have been detected in prostate

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: AR-α1A (Q365) polyclonal antibody detects endogenous levels of AR-α1A protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of AR-α1A (Q365) pAb at 1:500 dilution
Lane 1: HepG2 whole cell lysate (40ug)
Lane 2: PC3 whole cell lysate (40ug)
Lane 3: LO2 whole cell lysate (40ug)
Lane 4: HEK293T whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of AR-α1A (Q365) pAb in paraffin-embedded human brain tissue.

Bioworld Molecular Weight: ~ 51 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; ADRA1A; ADRA1C; α1A-AR; α-1A AR

Immunogen: Synthetic peptide, corresponding to amino acids 350-400 of Human AR-α1A.

Conjugate: Unconjugated

Modification: Unmodified