Product Description

AR-β2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90092-50, BS90092-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P07550(Human) P18762(Mouse) P10608(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat, zebrafish

Applications: WB, IHC, IP,

All Applications: WB:1:1,000-1:5,000
IHC:1:50-1:200

Background: Adrenergic receptors (ARs) (the term "adrenergic" reflects the alternative name for epinephrine, adrenaline) include four general types (a1, a2, b1 and b2) which are found in different target tissues and differ in their affinities and responses to various agonists and antagonists. cDNA clones have been isolated for all of the major AR subtypes and a number of closely related receptors have been identified by this approach. Each of the receptors have been shown to consist of single polypeptide chains which transverse the plasma membrane seven times, presumably forming a bundle of helices within the membrane. These transmembrane regions are hydrophobic and are interconnected by extracellular and intracellular hydrophilic loops. The coupling of ARs to specific intracellular effectors is mediated through diverse heterotrimeric G proteins and is regulated by G protein-coupled receptor kinases (GRKs), cAMP-dependent protein kinase A and protein kinase C directed phosphorylation. b2-adrenergic receptors bind cathecholamines (epinephrine, norepinephrine) and influence development, behavior, cardiac function, smooth muscle tone, and metabolism. b2-AR signaling complexes can contain C L-type calcium channel Ca(V)1.2, G protein, adenylyl cyclase, cAMP-dependent kinase, and PP2A phosphatase.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: AR-β2 polyclonal antibody detects endogenous levels of AR-β2 protein.

Bioworld Molecular Weight: 60 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of ADRB2 on zebrafish lysates using anti-ADRB2 antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-ADRB2 antibody. Counter stained with hematoxylin.

Alternative Name: ADRB2, ADRB2, ADRB2, ADRB2R, ADRBR, Adrenergic beta 2 receptor surface, Adrenoceptor beta 2 surface, B2AR, BAR, beta 2 adrenoceptor, Beta 2 adrenoreceptor, Beta-2 adrenergic receptor, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, BETA2AR, Catecholamine receptor, OTTHUMP00000160386,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified