Product Description

ARC1B Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18273-50, ES18273-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ARC1B AA range: 27-77

Isotype: IgG

Target: ARC1B

Specificity: This antibody detects endogenous levels of ARC1B at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 41kD

Fields: Endocytosis, Tight junction, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Bacterial invasion of epithelial cells, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Yersinia infection

Function: Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks
Similarity: Belongs to the WD repeat ARPC1 family
Similarity: Contains 6 WD repeats
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC

Subcellular Location: Cytoplasm, cytoskeleton Nucleus

Storage and Stability: -20°C/1 year

Gene Name: ARPC1B ARC41

Protein Name: ARC1B

Mouse Gene ID: 11867

Mouse SwissProt Number: Q9WV32

Rat Gene ID: 54227

Rat SwissProt Number: O88656

Research Use Only