Product Description

Artemis Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7173-50, ES7173-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity, it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: IHC, IF, ELISA

Alternate Names: DCLRE1C, ARTEMIS, ASCID, SCIDA, SNM1C, Protein artemis, DNA cross-link repair 1C protein, Protein A-SCID, SNM1 homolog C, hSNM1C, SNM1-like protein

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Artemis. AA range:482-531

Isotype: IgG

Target: Artemis

Specificity: Artemis Polyclonal Antibody detects endogenous levels of Artemis protein.

Dilution: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitously expressed, with highest levels in the kidney, lung, pancreas and placenta (at the mRNA level), Expression is not increased in thymus or bone marrow, sites of V(D)J recombination,

Molecular Weight (Da): 78kD

Fields: Non-homologous end-joining, Primary immunodeficiency

Function: Disease: Defects in DCLRE1C are a cause of Omenn syndrome (OS) [MIM: 603554]. OS is characterized by severe combined immunodeficiency associated with erythrodermia, hepatosplenomegaly, lymphadenopathy and alopecia. Affected individuals have elevated T-lymphocyte counts with a restricted T-cell receptor (TCR) repertoire. They also generally lack B-lymphocytes, but have normal natural killer (NK) cell function (T+ B- NK+)
Disease: Defects in DCLRE1C are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-positive with sensitivity to ionizing radiation (RSSCID) [MIM: 602450]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persi

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: DCLRE1C

Protein Name: Protein artemis

Mouse SwissProt Number: Q8K4J0

Research Use Only