Product Description

ARY2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18242-50, ES18242-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ARY2 AA range: 80-130

Isotype: IgG

Target: ARY2

Specificity: This antibody detects endogenous levels of ARY2 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 32kD

Fields: Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Chemical carcinogenesis - DNA adducts

Function: Catalytic Activity: Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine
Disease: Genetic variations in NAT2 determine N-acetylation polymorphism by a low or high NAT activity in the liver [MIM: 243400]. It has been implicated in the action and toxicity of amine-containing drugs, and in the susceptibility to bladder cancer and systemic lupus erythematosus. This isozyme is responsible for this polymorphism
Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens
Online Information: NAT alleles,Online Information: The Singapore human mutation and polymorphism database,Similarity: Belongs to the arylamine N-acetyltransferase family

Subcellular Location: Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: NAT2 AAC2

Protein Name: ARY2

Mouse Gene ID: 17961

Mouse SwissProt Number: P50295

Rat Gene ID: 116632

Rat SwissProt Number: P50298

Research Use Only