Product Description

ASB3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18237-50, ES18237-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ASB3 AA range: 30-80

Isotype: IgG

Target: ASB3

Specificity: This antibody detects endogenous levels of ASB3 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 57kD

Function: Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B
Pathway: Protein modification, protein ubiquitination
Similarity: Contains 1 SOCS box domain
Similarity: Contains 11 ANK repeats
Subunit: Interacts with TCEB2 and TNFRSF1B

Subcellular Location: ubiquitin ligase complex, nucleus, cytoplasm,

Storage and Stability: -20°C/1 year

Gene Name: ASB3

Protein Name: ASB3

Mouse Gene ID: 65257

Mouse SwissProt Number: Q9WV72

Research Use Only