Product Description

ASCC1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18235-50, ES18235-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ASCC1 AA range: 289-339

Isotype: IgG

Target: ASCC1

Specificity: This antibody detects endogenous levels of ASCC1 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous,

Molecular Weight (Da): 44kD

Function: Function: Enhances NF-kappa-B, SRF and AP1 transactivation
Similarity: Contains 1 KH domain
Subunit: Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3
Tissue Specificity: Ubiquitous

Subcellular Location: Nucleus Nucleus speckle Colocalizes with PRPF8 in nuclear speckles in the absence of DNA damage

Storage and Stability: -20°C/1 year

Gene Name: ASCC1 CGI-18

Protein Name: ASCC1

Mouse Gene ID: 69090

Mouse SwissProt Number: Q9D8Z1

Research Use Only