Product Description

ASPC1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18227-50, ES18227-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X, 17)(p11, q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ASPC1 AA range: 327-377

Isotype: IgG

Target: ASPC1

Specificity: This antibody detects endogenous levels of ASPC1 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous, Highly expressed in testis, heart, skeletal muscle and pancreas,

Molecular Weight (Da): 61kD

Fields: Transcriptional misregulation in cancer

Function: Disease: A chromosomal aberration involving ASPSCR1 may be a cause of papillary renal cell carcinoma (PRCC) [MIM: 605074]
Disease: Chromosomal aberrations involving ASPSCR1 are recurrent in alveolar soft part sarcoma (ASPS) [MIM: 606243]. Translocation t(X, 17)(p11, q25) with TFE3 forms a ASPSCR1-TFE3 fusion protein
Function: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface
Similarity: Contains 1 UBX domain
Subunit: Interacts with GLUT4
Tissue Specificity: Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas

Subcellular Location: Endomembrane system, Peripheral membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane, Peripheral membrane protein Cytoplasm Nucleus

Storage and Stability: -20°C/1 year

Gene Name: ASPSCR1 ASPL RCC17 TUG UBXD9 UBXN9

Protein Name: ASPC1

Mouse Gene ID: 68938

Mouse SwissProt Number: Q8VBT9

Research Use Only