Product Description

ASTL Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18225-50, ES18225-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ASTL AA range: 115-165

Isotype: IgG

Target: ASTL

Specificity: This antibody detects endogenous levels of ASTL at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in some ovarian carcinomas, Not detected in normal tissues,

Molecular Weight (Da): 47kD

Function: Enzyme Regulation: Inhibited by wide spectrum metalloproteinase inhibitor batimastat (BB-94). Also inhibited by EDTA
Similarity: Belongs to the peptidase M12A family
Tissue Specificity: Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in some ovarian carcinomas. Not detected in normal tissues

Subcellular Location: Cytoplasm Cell membrane Cytoplasmic vesicle, secretory vesicle, Cortical granule Probably exocytosed from cortical granules during post-fertilization Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles at postnatal (PN) day 3 Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization Upon fertilization, detected in the perivitelline space (PVS) and occasionally on the oolemma in 2-cell through morulae stages Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS)

Storage and Stability: -20°C/1 year

Gene Name: ASTL

Protein Name: ASTL

Mouse Gene ID: 215095

Mouse SwissProt Number: Q6HA09

Research Use Only