Product Description

AT8A1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18218-50, ES18218-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human AT8A1 AA range: 159-209

Isotype: IgG

Target: AT8A1

Specificity: This antibody detects endogenous levels of AT8A1 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Found in most adult tissues except liver, testis and placenta, Most abundant in heart, brain and skeletal muscle, Also detected in fetal tissues, Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle, Highly expressed in platelets (PubMed:30674456),

Molecular Weight (Da): 128kD

Function: Catalytic Activity: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Function: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles
Similarity: Belongs to the cation transport ATPase (P-type) family. Type IV subfamily
Tissue Specificity: Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. The long isoform is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle

Subcellular Location: Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane, Multi-pass membrane protein Cytoplasmic granule Cell membrane Endoplasmic reticulum Golgi apparatus Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:20947505) In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures and localizes to the plasma membrane (PubMed:20947505) Localizes to plasma membranes of red blood cells (By similarity)

Storage and Stability: -20°C/1 year

Gene Name: ATP8A1 ATPIA

Protein Name: AT8A1

Mouse Gene ID: 11980

Mouse SwissProt Number: P70704

Research Use Only